Everything about Kanamycin totally explained
| PubChem=6032
| DrugBank=APRD00026
| C=18 | H=36 | N=4 | O=11
| molecular_weight = 484.499
| bioavailability= very low after oral delivery
| metabolism = ?
| elimination_half-life= 2 hours 30 minutes
| excretion = ?
| pregnancy_category = ?
| legal_status = ?
| routes_of_administration= Oral,
intravenous,
intramuscular
}}
Kanamycin sulfate is an
aminoglycoside antibiotic, available in both and
intravenous forms, and used to treat a wide variety of
infections. Kanamycin is isolated from
Streptomyces kanamyceticus.
Pharmacology
Kanamycin works by affecting the
30S ribosomal subunit and causing a
frameshift mutation or it prevents the
translation of
RNA. This means that instead of a
codon CAT (for example in sequence CATG), a codon ATG is read by
aminoacyl tRNA (aa-tRNA). Aminoacyl tRNA is consequently carrying a different
amino acid, because the
anticodon on the aa-tRNA is different. The
protein needed can't be synthesized: depending on the site and severity of the frame shift, either a completely different protein is synthesized, or a protein similar to the one needed is synthesized, but is
folded incorrectly.
A bacterium is destroyed because it can't produce any of its proteins correctly.
Kanamycin isn't given to humans often because of its fairly toxic side-effects.
Side effects
Serious
side effects include changes in
hearing (either hearing loss or
ringing in the ears),
toxicity to kidneys, and
allergic reactions to the
drug.
Use in research
Genes encoding kanamycin resistance are commonly used as selectable markers in molecular biology. At least one such gene,
Atwbc19 is native to a plant species, of comparatively large size and its coded protein acts in a manner which decreases the possibility of
Horizontal Gene Transfer from the plant to bacteria; it may be incapable of giving resistance to kanamycin to bacteria even if gene transfer occurs.
Further Information
Get more info on 'Kanamycin'.
|
External Link Exchanges
Do you know how hard it is to get a link from a large encyclopaedia? Well we're different and will prove it. To get a link from us just add the following HTML to your site on a relevant page:
<a href="http://kanamycin.totallyexplained.com">Kanamycin Totally Explained</a>
Then simply click through this link from your web page. Our crawlers will verify your link, extract the title of your web page and instantly add a link back to it. If you like you can remove the words Totally Explained and embed the link in article text.
As long as your link remains in place, we'll keep our link to you right here. Please play fair - our crawlers are watching. Your site must be closely related to this one's topic. Any kind of spamming, dubious practises or removing the link will result in your link from us being dropped and, potentially, your whole site being banned. |
